When Wonder Buddy and Super Earl learn that the Evil Doctor Stinker is planning to shut down the only hamburger factory in town, they know they have to find the supervillain's secret lair---fast! Hopping into the Earl-mobile, they race into the yard next door where they come face-to-face with the new neighbors. At first, Mister the bulldog is alarmed by Wonder Buddy's laser-beam eyes (even though Buddy does not know how to turn them on), and Snowball the cat thinks that Earl is the funniest-looking mouse she's ever seen. But when Snowball ends up in mortal danger, Buddy and Mister team up to save the day, and Snowball and Earl discover that they have more in common than they thought.