In this reimagined Western, it is 1876, and Calamity Jane, Frank Butler, and Annie Oakley use their traveling show, "Wild Bill's Wild West," as a cover for hunting werewolves. After a hunt in which Jane receives a bite, she travels to Deadwood where it's rumored she can find a cure before the sickness takes hold of her. However, things aren't what they seem, and Frank and Annie race after Jane to warn her before it's too late.